Novel Pseudomonas aeruginosa Gene That Suppresses Tolerance to Carbapenems
نویسندگان
چکیده
منابع مشابه
Novel Pseudomonas aeruginosa gene that suppresses tolerance to carbapenems.
A biapenem-tolerant mutant of Pseudomonas aeruginosa was isolated by Tn1737KH insertion. The survival of the mutant 3 h after the addition of biapenem was about 1000 times greater than that of the wild type. The mutant was also tolerant to other biapenems, such as imipenem, panipenem, and meropenem.
متن کاملrpoN Gene of Pseudomonas aeruginosa Alters its 1 Susceptibility to Quinolones and Carbapenems 2 Running title : rpoN gene and tolerance in Pseudomonas aeruginosa 3
¶ Present address: Department of Molecular Biology and Microbiology, Case 9 Western Reserve University, School of Medicine, Cleveland, Ohio 44106, 10 USA. 11 *Corresponding author. Mailing address: Department of Microbiology, 12 Institute of Health Biosciences, The University of Tokushima Graduate 13 School, Tokushima 770-8504, Japan. 14 Phone: +81-88-633-7330. Fax: +81-88-633-7390. 15 E-mail a...
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متن کاملrpoN gene of Pseudomonas aeruginosa alters its susceptibility to quinolones and carbapenems.
The alternative sigma factor sigma54 has been implicated in diverse functions within the cells. In this study, we have constructed an rpoN mutant of Pseudomonas aeruginosa and investigated its importance as a target for antimicrobial agents, such as quinolones and carbapenems. The stationary-phase cells of the rpoN mutant displayed a survival rate approximately 15 times higher than that of the ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2003
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.47.9.2997-3001.2003